In vitro cytotoxicity of recombinant human-TNF-α and actinomycin D on canine normal and tumor cells

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  • AOKI Mica
    Departments of Veterinary Surgery, School of Agriculture, Osaka Prefecture University
  • KUWAMURA Mitsuru
    Departments of Veterinary Pathology, School of Agriculture, Osaka Prefecture University
  • KOTANI Takao
    Departments of Veterinary Pathology, School of Agriculture, Osaka Prefecture University
  • KATAMOTO Hiromu
    Departments of Veterinary Teaching Hospital, School of Agriculture, Osaka Prefecture University
  • KUBO Kihei
    Departments of Radiology, School of Agriculture, Osaka Prefecture University
  • NOMURA Koichi
    Departments of Veterinary Surgery, School of Agriculture, Osaka Prefecture University
  • SASAKI Nobuo
    Department of Veterinary Surgery, Graduate School of Agriculture and Life Sciences, the University of Tokyo
  • OHASHI Fumihito
    Departments of Veterinary Surgery, School of Agriculture, Osaka Prefecture University

書誌事項

タイトル別名
  • In Vitro Cytotoxicity of Recombinant Human-TNF-.ALPHA. and Actinomycin D on Canine Normal and Tumor Cells.
  • In vitro cytotoxicity of recombinant hu

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The in vitro cytotoxicity of recombinant human tumor necrosis factor-α (rh-TNF-α) and actinomycin D (ACT-D) on canine normal and tumor cells was investigated. rh-TNF-α showed dose-dependent cytotoxic and cell-growth inhibitory effects on cultured canine kidney carcinoma cells (CKCa-1). rh-TNF-α alone produced little cytotoxic effect on canine normal cells. However, combined with ACT-D, it showed moderate cytotoxicity on normal canine cells from the kidney medulla, spleen, heart muscle and lung. When the effects on the spontaneous tumor cells were examined, the combination of rh-TNF-α and ACT-D produced substantial cytotoxic effect on 60% of the tumor cells. All mammary mixed tumors and perianal gland tumors tested were susceptible to this combination. The data indicated the combination of rh-TNF-α and ACT-D have in vitro cytotoxicity on certain canine tumor cells.

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