犬における排泄性尿路造影の画質と造影剤誘発性腎症の発生防止に対するドパミンの効果 Effect of Dopamine on Excretory Urographic Image Quality and the Prevention of Contrast-Induced Nephropathy in Dogs

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Abstract

正常犬(実験1)と腎機能障害犬(実験2)を用いて,排泄性尿路造影の画質と造影剤誘発性腎症の発生におよぼす低用量ドパミンの効果について検討した.腎機能障害大は,ゲンタマイシンの大量投与によって作出した.各実験は,造影剤(iohexol)単独投与群(第1群),造影剤と静脈内輸液(0.9%生理食塩水)投与群(第2群)および第2群の内容に低用量のドパミンを加えた群(第3群)に分けて行った.RI(intrarcnal resistive index),血清BUNとクレアチニン値,造影剤排泄時間およびX線像の画質の各項目について評価した.第1群のRIは造影剤投与後,80分で上昇(P<0.05)したが,第3群のRIは48および72時間で低下した(P<0.05).第1群のBUN値は,第2および3群のそれより高値であった(P<0.05).X線検査では,造影剤排泄時間は,第2および3群で短縮したが,第2群の画質は第3群のそれより劣っていた.実験2では,第3群の画質でのみ腎構造が良好に描出された.造影剤と低用量ドパミンの併用によって,造影剤を追加することなく腎臓および腎孟造影の良好な画質が得られ,また腎尿細管が高濃度の造影剤に長時間暴露されることが避けられる.

The effect of low dose dopamine on the excretory urographic image quality and contrast media-induced nephropathy in normal dogs (experiment 1) and the dogs with decreased renal function (experiment 2) were assessed. In experiment 2, decreased renal function was induced by gentamicin overdose. In each experiment, animals were divided into 3 groups. In group 1, only contrast medium (iohexol) was administered. In group 2, contrast medium plus intravenous fluid (0.9% saline) were administered. And in group 3, contrast medium plus intravenous fluid and low dose dopamine were administered. Investigated parameters included intrarenal resistive index (RI), serum BUN and creatinine concentrations, contrast medium elimination time and radiographic image quality. In experiment 1, RI of group 1 increased at 80 min after contrast medium administration (p<0.05), but RI of group 3 decreased at 48 and 72 hr (p<0.05). Serum BUN concentration of group 1 was higher than that of group 2 and 3 (p<0.05); in radiographic examination, contrast medium elimination time decreased in group 2 and 3, but image quality of group 2 was inferior to that of group 3. In experiment 2, image quality of group 3 only provided adequate visualization of renal structures. The formula of contrast medium plus low dose dopamine was found to provide good nephrogram and pyelogram image quality without supplemental contrast medium, and to protect renal tubules from prolonged exposure to concentrated contrast medium.

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 63(4), 383-388, 2001-04

    Japanese Society of Veterinary Science

References:  26

Cited by:  1

Codes

  • NII Article ID (NAID)
    110003920618
  • NII NACSIS-CAT ID (NCID)
    AN00191788
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09167250
  • NDL Article ID
    5751491
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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