犬の正常精巣および精巣腫瘍におけるcyclinの免疫組織化学的解析
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- MURAKAMI Yuichi
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
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- TATEYAMA Susumu
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
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- UCHIDA Kazuyuki
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
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- YAMAGUCHI Ryoji
- Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
書誌事項
- タイトル別名
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- Immunohistochemical Analysis of Cyclins in Canine Normal Testes and Testicular Tumors.
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抄録
The expression of cyclins A, D1, D2 and E were examined immunohistochemically in 5 canine normal testes and 31 testicular tumors, including 14 seminomas, 11 Sertoli cell tumors and 6 Leydig cell tumors. In canine normal testes, cyclin A expression was detected in spermatogonia and primary spermatocytes. This suggests that A-type cyclins may play some role in canine spermatogenesis. Cyclin A expression was also observed in 13/14 (92.9%) seminomas and 2/11 (18.2%) Sertoli cell tumors, but no positive reaction was observed in Leydig cell tumors. Parallel examinations for cyclins D1, D2 and E gave negative results in canine normal testes and testicular tumors. High levels of cyclin A expression in canine seminomas indicate that the neoplastic germ cells may be arrested at the spermatogonia and primary spermatocyte stages of differentiation.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 63 (8), 909-912, 2001
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206424188416
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- NII論文ID
- 110003920715
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3MXntVKrsbs%3D
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- ISSN
- 13477439
- 09167250
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- HANDLE
- 10458/1181
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- NDL書誌ID
- 5888881
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- PubMed
- 11558548
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可