犬の正常精巣および精巣腫瘍におけるcyclinの免疫組織化学的解析

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  • MURAKAMI Yuichi
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
  • TATEYAMA Susumu
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
  • UCHIDA Kazuyuki
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
  • YAMAGUCHI Ryoji
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University

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  • Immunohistochemical Analysis of Cyclins in Canine Normal Testes and Testicular Tumors.

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The expression of cyclins A, D1, D2 and E were examined immunohistochemically in 5 canine normal testes and 31 testicular tumors, including 14 seminomas, 11 Sertoli cell tumors and 6 Leydig cell tumors. In canine normal testes, cyclin A expression was detected in spermatogonia and primary spermatocytes. This suggests that A-type cyclins may play some role in canine spermatogenesis. Cyclin A expression was also observed in 13/14 (92.9%) seminomas and 2/11 (18.2%) Sertoli cell tumors, but no positive reaction was observed in Leydig cell tumors. Parallel examinations for cyclins D1, D2 and E gave negative results in canine normal testes and testicular tumors. High levels of cyclin A expression in canine seminomas indicate that the neoplastic germ cells may be arrested at the spermatogonia and primary spermatocyte stages of differentiation.

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