Phylogenetic Analysis of the Hemagglutinin (H) Gene of Canine Distemper Viruses Isolated from Wild Masked Palm Civets (Paguma larvata)

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  • HIRAMA Kyoko
    Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
  • GOTO Yoko
    Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
  • UEMA Masashi
    Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
  • ENDO Yasuyuki
    Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
  • MIURA Ryuichi
    Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
  • KAI Chieko
    Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo

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Abstract

Hemagglutinin (H) gene of two CDV isolates, the Haku93 and Haku00 strains, from masked palm civets was molecularly analyzed. H genes of both two CDVs contained one open reading frame encoding 607 amino acids. Nucleotide and predicted amino acid sequences of H gene of the CDV Haku93 and Haku00 revealed high similarity to those of recent field isolates such as the Yanaka and Tanu96, while they showed limited identity to those of old vaccine strains. Potential N-linked glycosylation sites in both Haku93 and Haku00 were identical to other recent CDV isolates. Phylogenetic analysis revealed that the CDV strains derived from masked palm civets were classified into the group of recent Japanese CDV isolates.<br>

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