イヌエンドセリン受容体cDNAのクローニングおよび正常組織における発現

DOI 日本農学文献記事索引 Web Site Web Site 参考文献46件
  • YASUDA Nobutaka
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • TSUKUI Toshihiro
    Nippon Zenyaku Kogyo Co., Ltd.
  • MASUDA Kenichi
    Laboratory for Vaccine Design, Research Center for Allergy and Immunology, Yokohama Institute, RIKEN (The Institute of Physical and Chemical Research)
  • KAWARAI Shinpei
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • OHMORI Keitaro
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • MAEDA Sadatoshi
    Laboratory of Veterinary Internal Medicine, Faculty of Applied Biological Sciences, Gifu University
  • TSUJIMOTO Hajime
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo

書誌事項

タイトル別名
  • Cloning of cDNA Encoding Canine Endotherlin Receptors and Their Expressions in Normal Tissues
  • Cloning of cDNA Encoding Canine Endothelin Receptors and Their Expressions in Normal Tissues

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抄録

The receptors for endothelin (ET) family, ETA and ETB, were molecularly cloned and the expression of ETA and ETB as well as preproendothelin-1 (PPET-1, precursor of ET-1) was examined in normal canine tissues by RT-PCR. The entire open reading frames of the canine ETA and ETB were shown to encode 427 and 442 amino acid residues, respectively, showing from 87.4 to 97.3% sequence similarity to human, mouse, and rat counterparts. ETA and ETB mRNAs were ubiquitously expressed in a variety of canine tissues in this study and PPET-1 mRNA was detected in the tissues except for heart and liver. It was speculated that ET could play an important role in physiological events in most of the organs.<br>

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