コラーゲンの歯周治療への応用に関する実験病理学的研究　　コラーゲンの種類および架橋処理の相違が創傷治癒反応におよぼす影響について

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  • Experimental and histological studies of different cross-linking types of collagen materials implanted in rat palatal gingiva.
  • - コラーゲンの種類および架橋処理の相違が創傷治癒反応におよぼす影響について-

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Collagen membrane preparations were manufactured with the aim of enhancing would healing following periodontal surgery, and their effects on the process of would healing were studied by experiments. After cross-linking by various processing methods (with ultraviolet and hexamethylenediisocyanate) and to various extents, two types of collagen (atelocollagen and tendoncollagen) were implanted into the site of dissection of the palatal gingival tissue followed by planing of the root surface at the maxillary first molar region. The time course of healing responses was histopathologically investigated. Collagen implantation was found to inhibit apical migration of the junctional epithelium and accelerate fibrous connective tissue attachment to the root surface. Cross-linked atelocollagen was superior inbiocompatibility to the others and most prominently inhibited apical migration of the junctional epithelium.

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