Brain Link Proteins : New Insights for Hyaluronan-Binding Proteoglycans in Brain(<Special Issue>Roles of Extracellular Matrix in the Development and Regeneration of Nervous Systems) :

NDLデジタルコレクション 参考文献45件
  • OOHASHI,Toshitaka
    Department of Molecular Biology and biochemistry, Okayama University Graduate School of Medicine and Dentistry
  • NINOMIYA,Yoshifumi
    Department of Molecular Biology and biochemistry, Okayama University Graduate School of Medicine and Dentistry

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Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crtl1. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crtl1, brain-specific link protein gene, Brail, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.

収録刊行物

  • Connective tissue

    Connective tissue 35 (1), 25-30, 2003-03-25

    日本結合組織学会

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