原因不明反復流産患者に対する柴苓湯の有用性の検討 [in Japanese] The Effect of Sairei-to for Habitual Abortion [in Japanese]
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原因不明反復流産患者19例に対して, 柴苓湯8.1g/日を投与し, その妊娠予後, 抗体価の推移などにつき検討した。妊娠の成立は16例に認めた。16例中11例で生児を得た。新生児の体重はすべて正常範囲内で, (AGA) 生後1分の Apgar score はいずれも8点以上であった。自己抗体陽性患者は, 7例で, 抗体価が下降, もしくは陰性化した症例は4例で, いずれも妊娠が成立し, その予後も良好であったが, 抗体価不変の3例は, 1例が妊娠し分娩に至ったものの, 2例は妊娠の成立をみなかった。以上の結果から, 原因不明の反復流産症例に対する柴苓湯投与の有効性が示唆された。いずれの症例においても母児ともに副作用は認めなかった。作用機序, 投与方法など検討の余地は残るものの結果も良好なことから試みても良い方法と思われた。
Sairei-to was administered to 19 women who had experienced recurrent abortion of unknown cause, at a dose of 8.1g/day. Their prognosis of pregnancy was evaluated by observing the changes in autoantibody titer over time. Sixteen of the 19 women became pregnant, and 11 of these patients delivered live newborn infants. All of these newborn infants were within normal range in body weight, and had Apgar scores of 8 points or more (at one minute). Seven women were positive for autoantibodies. Four of these seven women showed a decrease in antibody titer or diasappearance of autoantibodies following treatment with Sairei-to, and became pregnant with good prognosis. The remaining three women, however, showed no changes in antibody titer. Two of these women had unsuccessful pregnancies, and one had a successful pregnancy and delivery. No adverse drug reactions were noted in either mothers or infants. These results suggest that Sairei-to possesses excellent clinical efficacy in women with recurrent abortion of unknown cause. Use of Sairei-to in such cases is thus likely warranted, although further investigation is required to clarify the mode of action and to establish the optimal dosage regimen.
- Kampo Medicine
Kampo Medicine 47(4), 631-634, 1997-01-20
The Japan Society for Oriental Medicine