Maintenance of a Round Cell Shape and Physiological Responsiveness to Insulin of Mature Adipocytes by Culturing in Type I Collagen Gel

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著者

    • HARIMOTO Masami
    • Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
    • HIROSE Motohiro
    • Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
    • HAYASHI Toshihiko
    • Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
    • ATOMI Yoriko
    • Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo

抄録

Cellular behavior including viability, cell shape, and insulin responsiveness was comparedamong three culture systems of mature adipocytes obtained from rat adipose tissues : in type I collagen gel, on type I collagen-coated dish, and floating in culture medium. Rat mature adipocytes cultured in the type I collagen gel maintained a round shape with terminal differentiation state as long as 50 days or more. The adipocytes retained a responsiveness to insulin as shown by leptin secretion. The multicellular organization comprising type I collagen gel and mature adipocytes appears functionally and structurally to be an adipose tissue-like construct.

収録刊行物

  • Connective tissue

    Connective tissue 32(1), 11-15, 2000-03-25

    日本結合組織学会

参考文献:  20件中 1-20件 を表示

各種コード

  • NII論文ID(NAID)
    110004002281
  • NII書誌ID(NCID)
    AN10169901
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    0916572X
  • データ提供元
    CJP書誌  NII-ELS  NDL-Digital 
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