Proteoglycans of Cartilage Extracellular Matrix

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Author(s)

    • WATANABE Hideto
    • Institute for Molecular Science of Medicine, Aichi Medical University

Abstract

Cartilage is localized on the surface of joint and helps joint movement. During development, cartilage serves as template for bones. Extracellular matrix of cartilage contains two major structures: fibrils and fibers of collagens, and the proteoglycan aggregates. Other matrix molecules, interacting each other, contribute to formation of a highly integrated structure of cartilage. Cartilage contains a variety of proteoglycans including aggrecan, versican, perlecan, and small leucine-rich proteoglycans. Recent studies using knockout mice of these proteoglycans revealed their in vivo functions. In this review, roles of these proteoglycans in cartilage development and its homeostasis are discussed.

Journal

  • Connective tissue

    Connective tissue 32(3), 287-294, 2000-09-25

    日本結合組織学会

References:  61

Codes

  • NII Article ID (NAID)
    110004002405
  • NII NACSIS-CAT ID (NCID)
    AN10169901
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    0916572X
  • Data Source
    CJP  NII-ELS  NDL-Digital 
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