Expression of Clara Cell Secretory Protein in the Lungs of Rats Exposed to Crystalline Silica <i>In Vivo</i>

• Morimoto Yasuo

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Nagatomo Hiroko

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Hirohashi Masami

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Oyabu Takako

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Ogami Akira

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Yamato Hiroshi

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Kuroda Kaori

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Obata Yasuko

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Higashi Toshiaki

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

• Tanaka Isamu

  Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health

書誌事項

タイトル別名

• Expression of Clara Cell Secretory Protein in the Lungs of Rats Exposed to Crystalline Silica In Vivo

抄録

It has been theorized that Clara cell secretion protein (CCSP) plays a critical role in regulating the acute inflammatory response in the lung. We hypothesized that CCSP is also related to lung injury induced by occupational dust. The present study was conducted to investigate the time course of the expression of CCSP in lungs exposed to crystalline silica in vivo. Male Wistar rats were administered 1 mg or 2 mg of silica suspended in saline by a single intratracheal instillation and were sacrificed at 3 d, 1 wk, 1 month, 3 months and 6 months of recovery time. The expression of CCSP was observed by RT-PCR and western blot analysis. Exposure to 2 mg of silica decreased in levels of CCSP mRNA at 3 d, 1 wk, 1 month and 6 months following intratracheal instillation. The protein level of CCSP in silica-exposed rats was decreased at 3 d, 7 d and 1 month after a single instillation of 2 mg. The decreases in CCSP at the acute phase in this experiment suggest that CCSP may regulate the acute injury of the lung exposed to silica.<br>

収録刊行物

• ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ

  ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ 47 (6), 504-509, 2005

  公益社団法人 日本産業衛生学会

キーワード

• CCSP
• Crystalline silica
• Clara cell

詳細情報

• CRID: 1390282679431732352
• NII論文ID: 130004447316
• NII論文ID: 110004020576
• NII書誌ID: AA11090645
• DOI: 10.1539/joh.47.504
• COI: 1:CAS:528:DC%2BD28Xit1Kkug%3D%3D
• ISSN: 13489585
• ISSN: 13419145
• NDL書誌ID: 7731131
• Web Site: http://id.ndl.go.jp/bib/7731131
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7731131
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1539%2Fjoh.47.504
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1539/joh.47.504
• Web Site: https://search.jamas.or.jp/link/ui/2006280509
• 本文言語コード: en
• データソース種別:
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