Inhibitory Effects of Prior Low-dose X-ray Irradiation on Carbon Tetrachloride-induced Hepatopathy in Acatalasemic Mice

• YAMAOKA Kiyonori

  Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School

• KATAOKA Takahiro

  Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School

• NOMURA Takaharu

  Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry

• TAGUCHI Takehito

  Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School

• WANG Da-Hong

  Public Health, Okayama University Medical School

• MORI Shuji

  Pharmacology, Okayama University Medical School

• HANAMOTO Katsumi

  Chair of Medical Radioscience, and Department of Public Health and Pharmacology, Okayama University Medical School

• KIRA Shohei

  Public Health, Okayama University Medical School

抄録

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCs^bCs^b) mouse of C3H strain are lower than those of the normal (C3H/AnLCs ^aCs^a) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.<br>

収録刊行物

• Journal of Radiation Research

  Journal of Radiation Research 45 (1), 89-95, 2004

  Journal of Radiation Research 編集委員会

キーワード

• Acatalasemic mouse
• Catalase
• CCl₄
• Hepatotoxicity
• Low-dose X-irradiation
• Antioxidant substances

詳細情報

• CRID: 1390282680192635776
• NII論文ID: 110004040997
• NII書誌ID: AA00705792
• DOI: 10.1269/jrr.45.89
• ISSN: 13499157
• ISSN: 04493060
• NDL書誌ID: 6905673
• PubMed: 15133295
• Web Site: https://ousar.lib.okayama-u.ac.jp/48708
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6905673
• Web Site: http://academic.oup.com/jrr/article-pdf/45/1/89/6146555/jrr-45-89.pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10918534
• Web Site: https://search.jamas.or.jp/link/ui/2005231804
• 本文言語コード: en
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