Chromosomal Aberrations in Lymphocytes of Lung Cancer Patients Treated with Carbon Ions

• LEE Ryonfa

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• YAMADA Shigeru

  Charged Particle Therapy Center Hospital, National Institute of Radiological Sciences

• YAMAMOTO Naoyoshi

  Charged Particle Therapy Center Hospital, National Institute of Radiological Sciences

• MIYAMOTO Tadaaki

  Charged Particle Therapy Center Hospital, National Institute of Radiological Sciences

• ANDO Koichi

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• DURANTE Marco

  Department of Physics, University `Federico II', Monte S. Angelo

• TSUJII Hirohiko

  Charged Particle Therapy Center Hospital, National Institute of Radiological Sciences

Abstract

The purpose of this study is to investigate the normal tissue damage caused by carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during, and after radiotherapy, using the techniques of fluorescence in situ hybridization (FISH) and chemically induced premature chromosome condensation (PCC). Twenty-two lung cancer patients treated at HIMAC (Heavy Ion Medical Accelerator in Chiba) entered the study and signed an informed consent. Frequencies of lymphocytes with chromosomal aberrations at the end of carbon-ion therapy varied among the patients. This frequency was significantly correlated to the radiation field size and weakly correlated to the counts of white blood cells and lymphocytes during the treatment. As a result, we have found that chromosomal aberrations in peripheral blood lymphocytes from patients treated for lung cancer by carbon-ions were dependent on target volume, possibly reflecting the increased involvement of lymph nodes in the target field.<br>

Journal

• Journal of Radiation Research

  Journal of Radiation Research 45 (2), 195-199, 2004

  Journal of Radiation Research Editorial Committee

Keywords

• Chromosomal aberrations
• Heavy ions
• Radiation therapy
• Lung cancer
• Human lymphocytes

Details

• CRID: 1390001205216343936
• NII Article ID: 110004041016
• NII Book ID: AA00705792
• DOI: 10.1269/jrr.45.195
• ISSN: 13499157
• ISSN: 04493060
• NDL BIB ID: 7014478
• PubMed: 15304960
• Web Site: http://id.ndl.go.jp/bib/7014478
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7014478
• Web Site: http://academic.oup.com/jrr/article-pdf/45/2/195/2728274/jrr-45-195.pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10918558
• Web Site: https://search.jamas.or.jp/link/ui/2006149308
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • NDL-Digital
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed