Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs

Author(s)

Abstract

Methods to predict the responsiveness of a particular tumor to a particular anticancer drug are desirable not only for chemotherapy but also for chemoradiotherapy. Here, we examined the effects of viral or activated oncogenes on sensitivity to anticancer drugs by using SHOK (Syrian hamster Osaka-Kanazawa) cells and their transfectants. The IC<sub>50</sub> of each transfectant was compared with that of the pSV2Neo transfected control. Cells transfected with the c-<i>myc</i>, v-<i>mos</i>, or v-<i>fgr</i> gene increased their sensitivity to bleomycin, while those transfected with the H-<i>ras</i> gene developed resistance. Resistance to cisplatin was conferred by the introduction of the H-<i>ras</i> or c-<i>cot</i> gene. In the case of adriamycin, the c-<i>myc</i> or c-<i>cot</i> transfectant increased sensitivity and the H-<i>ras</i> transfectant decreased it. Mitomycin C resistance was observed by the introduction of the K-<i>ras</i> gene. Thus, the H-<i>ras</i> gene was found to be involved in the development of resistance to three of the four anticancer drugs. In addition, we have for the first time shown that <i>mos</i> and <i>cot</i> have an effect on sensitivity to three and all of the four anticancer drugs, respectively. These results suggest that the expression of each oncogene would differently affect sensitivity to the four anticancer drugs used in this study, and this property could be a possible marker to predict chemosensitivity.<br>

Journal

  • Journal of Radiation Research

    Journal of Radiation Research 46(2), 197-203, 2005-06-30

    Journal of Radiation Research Editorial Committee

References:  37

Codes

  • NII Article ID (NAID)
    110004041116
  • NII NACSIS-CAT ID (NCID)
    AA00705792
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    04493060
  • NDL Article ID
    7345068
  • NDL Source Classification
    ZS45(科学技術--医学--放射線医学)
  • NDL Call No.
    Z53-P232
  • Data Source
    CJP  NDL  NII-ELS  IR  J-STAGE  NDL-Digital 
Page Top