巨核球・血小板系列の遺伝子発現に関与する転写因子  [in Japanese] Transcription Factors Responsible for Megakaryocyte-specific Gene Expression  [in Japanese]

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Author(s)

    • 土井 健史 DOI Takefumi
    • 大阪大学大学院薬学研究科蛋白情報解析学分野 Graduate School of Pharmaceutical Sciences, Osaka University

Abstract

  Megakaryocytes are the hematopoietic precursors of platelets, which play an essential role in thrombosis and hemostasis. Platelet factor 4 (PF4) is expressed exclusively in megakaryocytes and platelets and serves as a lineage-specific marker of megakaryocytic differentiation. We previously characterized a number of upstream enhancer and repressor elements and demonstrated that GATA-1 and ETS-1 are important for PF4 gene expression. Recently, we have determined the novel regulatory element termed “TME” in the PF4 promoter and identified a group of binding proteins from megakaryocytic HEL cells. Here we review the function of these proteins in PF4 gene expression and discuss megakaryocyte-specific gene expression and megakaryocytepoiesis.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 125(9), 685-697, 2005-09-01

    The Pharmaceutical Society of Japan

References:  47

Codes

  • NII Article ID (NAID)
    110004042056
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00316903
  • NDL Article ID
    7473405
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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