Relationship Between Growth and Plasma Concentrations of Ghrelin and Growth Hormone in Juvenile Beagle Dogs

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  • YOKOYAMA Masayuki
    Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki
  • MURAKAMI Noboru
    Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki
  • NAGANOBU Kiyokazu
    Department of Veterinary Hospital, Faculty of Agriculture, University of Miyazaki
  • HOSODA Hiroshi
    National Cardiovascular Center Research Institute
  • KANGAWA Kenji
    National Cardiovascular Center Research Institute
  • NAKAHARA Keiko
    Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki

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Other Title
  • 成長期ビーグル犬のグレリンと成長ホルモン分泌様態(生理学)
  • 成長期ビーグル犬のグレリンと成長ホルモン分泌様態

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Abstract

Although the release of growth hormone (GH) is known to be regulated mainly by GH-releasing hormone (GHRH) and somatostatin (SRIF) secreted from the hypothalamus, ghrelin also may be involved in GH release during juvenile period. We have examined plasma concentrations of acylated ghrelin, desacyl ghrelin, and GH in juvenile beagle dogs. Plasma acylated and desacyl ghrelin levels changed through aging; however, there was no closely correlation between ghrelin, body weight and circulating GH levels during juvenile period. The increase in body weight was essentially linear until 8 months of age, whereas plasma GH concentrations exhibited bimodal peaks for the meanwhile. The results suggest that ghrelin may not play internal cueing in GH secretion in juvenile beagle dogs.<br>

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