防風通聖散の減量効果の検討 The Effect of Bofutsushosan on Weight Reduction in Humans

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外来を受診した肥満患者127例に一律に防風通聖散(Bo)を投与し, 6カ月以上服薬できた33例についてエキス剤の体重減量効果を検討した。対象例の腹力は5段階で(4)以上の強が多かったが, これは腹痛下痢などの副作用で長期投与ができなかった9例で中間(3)が多かったのに比較して, 腹力の強さの点で有意に高かった。服薬後の食欲低下は16例に認められた。食欲低下例と食欲不変例の投与前の体重はそれぞれ67.1±2.5kg, 75.9±2.4kgであり, 推計学的有意差を認めた。食欲低下例の体重の変化は-4.8±1.0kgで, 食欲不変例の-1.4±0.7kgに比較して明らかな差がみられた。血中中性脂肪値はBo投与後有意に低下した。作用機序として麻黄, 荊芥, 大黄, 連翹, 甘草によるAdrenalin β_3 receptorの活性化だけでなく, 大黄と山梔子による向精神作用が推測された。近年本薬に関する重篤な副作用報告がなされている。本剤の投与対象は腹力が強(4)以上が望ましく, 長期投与は食欲低下が認められる例によいと思われた。

We administered Bofutsushosan (Bo) to 127 obese patients who consulted our clinic, and investigated the effect of this herbal formula on reducing body weight in33obese patients who received continuous adminis tration for more than six months. The abdominal muscle tension of these 33 patients was assessed mainly as "strong" (four) under the five-grade scale of Kampo diagnostics, which was higher than that of 9 other patients with side effects (including diarrhea and abdominal pain) assessed mainly as "middle" (three). Sixteen patients reported a decrease in appetite following administration of Bo. Weight before medication in the patients with decreased appetite was 67.1±2.5kg, and that in 17 patients with unchanged appetite was 75.9±2.4kg. There was a significant difference between the two. Weight change in the patients with decreased appetite was -4.8±1.0kg and was significantly lower than -1.4±0.7kg in the patients with unchanged appetite. Their blood triglycerides levels decreased significantly following administration of Bo. This decrease in appetite was considered to be due not only to activation of the adrenaline β_3 receptor, through the administration of Ephedrae Herba, Schizonepetae Spica, Rhei Rhizoma, Forsythiae Fructus and Glycyrrhizae Radix but also to the psychotropic actions of Ephedra Herba, Rhei Rhizoma and Gardeniae Fructus. Recently severe side effects of Bo have been reported. This study suggested that patients showing a grade of strong (four) or more in abdominal muscle tension, were indicated for this treatment and that the long-term administration of this herbal formula should be continued in patients whose appetite was identified as being suppressed.

収録刊行物

  • 日本東洋醫學雜誌

    日本東洋醫學雜誌 56(6), 933-939, 2005-11-20

    社団法人日本東洋医学会

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各種コード

  • NII論文ID(NAID)
    110004050559
  • NII書誌ID(NCID)
    AN00015774
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    02874857
  • NDL 記事登録ID
    7764273
  • NDL 雑誌分類
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL 請求記号
    Z19-246
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS  J-STAGE 
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