Effects of voluntary resistance exercise and pulse patterned high‐protein snack on bone mass, composition and strength in rats given glucocorticoid‐injections

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  • 自発的レジスタンス運動と高タンパク質パルスフィーディングがグルココルチコイド投与ラットの骨重量，骨組成および骨強度に及ぼす影響
  • ジハツテキ レジスタンス ウンドウ ト コウタンパクシツ パルスフィーディング ガ グルココルチコイド トウヨ ラット ノ コツジュウリョウ コツソセイ オヨビ コツキョウド ニ オヨボス エイキョウ
  • Effects of voluntary resistance exercise and pulse patterned high-protein snack on bone mass, composition and strength in rats given glucocorticoid-injections

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Abstract

We examined the effects of a voluntary resistance exercise (climbing) together with high‐protein snacks (pulse pattern) on bone mass and strength in rats given glucocorticoid‐injections (2 mg/kg/day) as a model of age‐related ostepenia. Sixty‐four male Wistar rats, 10 weeks of age, were assigned to low protein (15% of total food intake) or normal protein (20%) diet groups. Half of the rats were exercised daily during dark period (20:00–8:00 h). These groups were furter divided into groups that received no snack or a pulse pattern high‐protein snack (75% of dietary protein) during resting period. All groups were meal‐fed at 8:30–9:30 h and 20:30–21:30 h and the snack was fed at 12:30–13:00 h for 8 weeks. Energy intake was approximately equal in all groups. The exercise groups were forced to climb a wire‐mesh tower cage (20 cm diameter × 200 cm height) to drink water from a bottle set at the top. Bone weight and calcium content were increased by climbing with pulse pattern high‐protein snacks. Climbing significantly increased bone maximumload and structural stiffness. However, no differences in bone mass or strength were observed between low and normal protein feeding groups, These results suggest that resistance exercise protects against the development of osteoporosis associated with aging. Pulse pattern high‐protein snacks may enhance the effects of exercise.

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