Bovine Leukemia Virus High Tax Molecular Clone Experimentally Induces Leukemia/Lymphoma in Sheep
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- OKADA Kosuke
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- NAKAE Norihiro
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- KURAMOCHI Konomi
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- YIN Shan-ai
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- IKEDA Manabu
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- TAKAMI Shigeaki
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- HIRATA Tou-ichi
- Field Science Center, Faculty of Agriculture, Iwate University
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- GORYO Masanobu
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- NUMAKUNAI Shigeru
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- TAKESHIMA Shin-nosuke
- Retrovirus Research Unit, RIKEN
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- TAKAHASHI Masahiko
- Retrovirus Research Unit, RIKEN
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- TAJIMA Shigeru
- Retrovirus Research Unit, RIKEN
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- KONNAI Satoru
- Graduate School of Veterinary Medicine, Hokkaido University
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- ONUMA Misao
- Graduate School of Veterinary Medicine, Hokkaido University
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- AIDA Yoko
- Retrovirus Research Unit, RIKEN
Bibliographic Information
- Other Title
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- BLV tax遺伝子分子クローン接種ヒツジにおけるリンパ腫の発症
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Abstract
Sheep were inoculated with high tax coded pBLV-IF (H group, Nos.1-5) of bovine leukemia virus (BLV), wild tax coded pBLV-IF (W group, Nos. 6-11), or control plasmid (C group, Nos. 12-14). During the observation period (4 to 46 months), 5 of 5 cases in H group and 3 of 6 cases (Nos. 6, 7, 9) in W group became positive for gp 51. Only 1 case in H group became leukemic, and one case each of H and W groups developed lymphoma. In No. 3, lesions were found in multiple organs including the lymph nodes, gastrointestinal tract following abomasum, and heart. In No. 6, lesions of lymphoma were found only in the jejunum and heart. Morphologically, small to middle-sized lymphocytic neoplastic (NP) cells were found in both cases, but lymphoblastic NP cells were found only in No. 3. By immunohistochemical examination, the phenotypes of NP cells were determined as CD1-, CD4-, CD5--, CD8α-, sIgM+, λ light chain+, B-B4+, MHC class II+ in both case. The results of this study indicate that inoculation of pBLV-IF can induce lymphocytic and lymphoblastic leukemia/lymphoma in sheep. Additionally, it is suggested that the expression rate of tax gene is not associated with the development of leukemia/lymphoma in sheep experimentally inoculated with pBLV-IF.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 67 (12), 1231-1235, 2005
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681402127488
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- NII Article ID
- 110004062321
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 7776670
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed