粒子法による血小板凝集過程の数値シミュレーション手法の提案(J06-3 イメージベースト達成バイオメカニクス解析(3),J06 イメージベースト達成バイオメカニクス解析)

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  • Proposal of a particle method simulation of thrombogenesis

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The purpose of this study is to propose a computer simulation method using particle method to analyze aggregation process of platelets in blood flow. We applied the MPS method, which has been developed for incompressible fluid based on Navier-Stokes equations, to plasma flow analysis. Adhesion of platelets to exposed subendothelium was modeled by introducing attractive force between the platelets and the injured wall. In addition, force acted on among aggregated platelets was considered to express the deformation of the aggregation as a solid. Two-dimensional simulations revealed that the proposed method expresses initial thrombogenesis, growth of the thrombus, and the destruction of thrombus. It was shown that the Reynolds number affects the number of the aggregated platelets, indicating fluid mechanical factors play an important role in thrombosis caused by platelets aggregation.

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