脳動脈瘤の発生および進展に関する計算力学シミュレーション(OS16f 生体力学における新しい計算解析手法)

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タイトル別名
  • A Numerical Simulation Study On The Initiation And Development Of Intracranial Aneurysms

抄録

The genesis and development of intracranial aneurysm have long been of interest but remain not understood. In the present study we simulate the progression of intracranial aneurysms by constructing a computational model of a curved artery. It is hypothesized that high local wall shear stress above a threshold value will lead to degeneration of the arterial wall mechanical properties. Our computer simulation shows that evenif the wall shear stress inside a saccular aneurysm is low, aneurysm development can occur due to degeneration of the wall distal and proximal to the aneurysm. The interaction between the geometry change and the wall degeneration is key to the development of aneurysms.

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