Dynamic Response to Mechanical Stimulation in Myoblasts

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An experiment was carried out to investigate the morphological response of mechanically stimulated myoblasts that were cultured on a collagen-coated silicone ribbon and were subjected to tension for 6 hours. Images of the cells were taken by a CCD camera and input into a computer every 10 minutes for 8 hours. Both morphological change represented by a shape index (SI) and cumulative migration of the cells were measured every hour. An increase of the SI and decrease of the migration velocity were observed during tensile loading. Considering the cell structure, it is considered that hydrodynamic force of the cytosol would act on cytoskeletons due to the deformation of the cell. The fluid-structure interaction analysis was carried out to estimate the stress of the filament, where the actin filament and cytosol were modeled as an elastic cylinder and viscous fluid, respectively. The results of the calculation suggested that the rounding of the cell might not be caused by the break of the filament due to the hydrodynamic force.

収録刊行物

  • JSME international journal. Series C, Mechanical systems, machine elements and manufacturing

    JSME international journal. Series C, Mechanical systems, machine elements and manufacturing 44(4), 920-927, 2001-12-01

    一般社団法人日本機械学会

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各種コード

  • NII論文ID(NAID)
    110004164344
  • NII書誌ID(NCID)
    AA11179487
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13447653
  • NDL 記事登録ID
    6014969
  • NDL 雑誌分類
    ZN11(科学技術--機械工学・工業)
  • NDL 請求記号
    Z53-Y272
  • データ提供元
    CJP書誌  NDL  NII-ELS  J-STAGE 
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