Molecular Genetic Study of Dental Caries Susceptibility in Mice
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- Uematsu Teruki
- Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
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- Shimizu Kunihiko
- Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
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- Nakamura Hitoshi
- Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
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- Asada Yosinobu
- Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine
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- Maeda Takahide
- Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
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Abstract
The purpose of this study was to identify the major candidate chromosome influencing susceptibility to dental caries in mice and to detect the region that contains it. Genetic factors affecting dental caries in mice were examined using two inbred strains of mice, C57BL/6J and C3H/HeJ, and these genetic crosses were inoculated with Streptococcus mutans serotype c (1.0 x 109 CFU/mouse). The caries scores for C3H/HeJ and C57BL/6J were 3.1±2.6 and 39.8±12.6 (Mean±S.D.), respectively. The mean caries score of the F1 hybrids was 17.6 ±13.2 (Mean±S.D.) which was in the range 1 to 46. The caries scores of F2 [(C57BL x C3H) x (C57BL x C3H)] mice had an extensive range from 0 to 68. These findings suggested that some genes play roles in caries development.<br>Based on our results with the genetic crosses, we used F2 intercross mice to investigate candidate chromosomal linkages using DNA pooling methods and obtained a valuable linkage on chromosomes 2 and 17. Thus, we concluded that one of the candidate genes controlling the genetic difference for the dental caries promoting ability between C3H/HeJ and C57BL/6J might be located on chromosomes 2 and 17.
Journal
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- International Journal of Oral-Medical Sciences
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International Journal of Oral-Medical Sciences 1 (1), 33-39, 2002
Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo
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Keywords
Details 詳細情報について
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- CRID
- 1390282680186246528
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- NII Article ID
- 110004313843
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- NII Book ID
- AA11830559
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- COI
- 1:CAS:528:DC%2BD3sXlslakt7g%3D
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- ISSN
- 21854254
- 13479733
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed