Odontogenic Keratocyst, Orthokeratinized Odontogenic Cyst and Epidermal Cyst: An Immunohistochemical Study Including Markers of Proliferation, Cytokeratin and Apoptosis Related Factors

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  • Koizumi Yasuyuki
    Department of Pathology, Nihon University School of Dentistry at Matsudo

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Objective: There are microscopic similarities among odontogenic keratocyst (OKC), orthokeratinized odontogenic keratocyst (OOC) and epidermal cyst (EDC). This study was to compare with cell proliferation, cell differentiation and apoptosis related factors in OKC, OOC and EDC in order to clarify the characters and category of three hitstopathologically similar cysts.<br>Material and Methods: Fourteen cases of OKC, nine cases of OOC and eighteen cases of EDC were examined immunohistochemically using antibodies against Ki-67, cytokeratins (CK7, 10, 10/13, 17, 18, 19, 20) and apoptosis related factors (bcl-2 and Bax).<br>Results: Ki-67 labeling index in OKC was statistically higher than that in OOC and EDC (p<0.05). And that in OOC was higher in EDC (p<0.05). In OKC, CKs and bcl-2 expression patterns were different from OOC and EDC, while both OOC and EDC showed similar reactivity with CKs and bcl-2.<br>Conclusions: The present results suggested that OKC had high cellular proliferation and was relatively low differentiation as compare with OOC and EDC. In addition, there was participation of apoptosis suppressor in OKC. The character of OOC occupied an intermediate position between OKC and EDC. Therefore, it was possible to consider OOC as a distinct entity from OKC. EDC had the lowest cellular activity in the three cysts and it was comparatively maturated lesion.

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  • ＩＪＯＭＳ

    ＩＪＯＭＳ 2 (1), 14-22, 2004

    日本大学松戸歯学部 口腔科学研究所

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