Characterization of an autolysin mutant of Porphyoromonas gingivalis

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  • Porphyromonas gingivalisの自己融解酵素変異株の性状
  • Porphyromonas gingivalis ノ ジコ ユウカイ コウソ ヘンイカブ ノ セイジョウ
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Abstract

The results of a BLAST search for autolysin indicated that one ORF was indentified as an autolysin which had 39% homology (58/147 amino acids) with the N-acetylmuramoyl-L-alanine amidase like protein of Clostridium tetani. This autolysin mutant of Porphyromonas gingivalis was constructed by alleic exchange. The growth curve of the autolysin mutant was the same as that of parent strain. However, the morphology of the autolysin mutant altered into chain forms at the early logphase. These results indicate that this autolysin may play an important role in cell division in P. gingivalis.

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