Nestin Expression in Vascular Malformations: A Novel Marker for Proliferative Endothelium

• SHIMIZU Tatsuya

  Department of Neurosurgery, Gunma University Graduate School of Medicine

• SUGAWARA Ken-ichi

  Department of Neurosurgery, Gunma University Graduate School of Medicine

• TOSAKA Masahiko

  Department of Neurosurgery, Gunma University Graduate School of Medicine

• IMAI Hideaki

  Department of Neurosurgery, Gunma University Graduate School of Medicine

• HOYA Katsumi

  Department of Neurosurgery, Koshigaya Hospital, Dokkyo University School of Medicine

• TAKEUCHI Toshiyuki

  Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University

• SASAKI Tomio

  Department of Neurosurgery, Neurological Institute, Graduate School of Medical Sciences, Kyushu University

• SAITO Nobuhito

  Department of Neurosurgery, Gunma University Graduate School of Medicine

抄録

Cavernous angiomas (CAs) and arteriovenous malformations (AVMs) sometimes show growth or de novo appearance. Proliferative capacity of the endothelium is evident in such malformations. Intermediate filament nestin is a newly identified marker for proliferative endothelium, which was originally detected in the neuroepithelial stem cells of the embryonal central nervous system. Immunohistochemical analysis of nestin was evaluated as a marker for proliferative capacity of endothelial cells by comparison with proliferating cell nuclear antigen (PCNA). Sixteen of 27 CAs and 13 of 20 AVMs were positive for nestin. Likewise, 12 of 27 CAs and 10 of 20 AVMs were positive for PCNA. Nestin staining was stronger in the typical malformative vessels of CAs than in AVMs, in both the endothelial cells and the interstitial cells. Newly formed endothelial cells expressed nestin strongly in the reactive tissues including organizing or encapsulated hematomas. These results suggest that neovascularization occurs in the process of repeated bleeding and remodeling of hematomas.<br>

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 46 (3), 111-117, 2006

  一般社団法人 日本脳神経外科学会

キーワード

• nestin
• cavernous angioma
• arteriovenous malformation
• endothelial cell

詳細情報

• CRID: 1390282680027191168
• NII論文ID: 110004656790
• NII書誌ID: AN00358613
• DOI: 10.2176/nmc.46.111
• COI: 1:STN:280:DC%2BD287ntFCrtg%3D%3D
• ISSN: 13498029
• ISSN: 04708105
• Web Site: http://www.jstage.jst.go.jp/article/nmc/46/3/46_3_111/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007064611
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可