食物摂取と唾液  [in Japanese] Food Intake and Saliva  [in Japanese]

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Author(s)

    • 勝川 秀夫 KATSUKAWA HIDEO
    • 朝日大学歯学部口腔機能修復学講座口腔生理学分野 Department of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
    • 硲 哲崇 SAKO NORITAKA
    • 朝日大学歯学部口腔機能修復学講座口腔生理学分野 Department of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
    • 江口 公人 EGUCHI KIMIHITO
    • 朝日大学歯学部口腔機能修復学講座口腔生理学分野 Department of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
    • 中橋 章泰 NAKAHASHI AKIHIRO
    • 朝日大学歯学部口腔機能修復学講座口腔生理学分野 Department of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
    • 小林 倫也 KOBAYASHI MICHIYA
    • 朝日大学歯学部口腔機能修復学講座口腔生理学分野 Department of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry
    • 杉村 忠敬 SUGIMURA TADATAKA
    • 朝日大学歯学部口腔機能修復学講座口腔生理学分野 Department of Oral Physiology, Division of Oral Functional Science and Rehabilitation, Asahi University School of Dentistry

Abstract

ヒトをはじめ動物は食物中にしばしば含まれる毒物に対し,それを無害化する手段を進化の過程で獲得してきた.例えば,食物中のタンニンは動物に対しさまざまな有害作用をもたらすが,クマやヘラジカのようにタンニンを含む植物を常食とする動物は唾液の中にその毒性を低下させる高プロリン・タンパク(PRP)を持つようになった.また,ラットやマウスは本来このタンパクを持たないが,タンニンを含む飼料を数日間食べると唾液中にPRPが誘導され生存することができる.一方,このタンパクを誘導できないハムスターはやせ衰え死んでしまう.パパイン(システインプロテアーゼ)やカプサイシン(唐辛子の辛味成分)により誘導されるシスタチンも同じ範疇に属するペプチドと思われるが,PRPに比べ未だ情報量は少ない.本稿では,食物中の毒物・侵害物質の処理に関係すると思われる唾液タンパクについて解説する.

Animals have evolved tools for coping with the toxic substances often contained in food. Proline-rich protein, found in saliva only, is a well-known example of such tools. This protein binds to the tannins that occur widely in plant foodstuff, preventing them from being absorbed from the gut, and attenuating their toxic effects (digestive trouble, carcinogenesis, liver disease and so on). Of the species without this salivary protein, rats and mice can produce it by ingesting tannin diets for a few days, but hamsters can not. When fed such diets, rats and mice live normally whereas hamsters deteriorate and die. Cystatin S (a cysteine protease inhibitor) is another example. Rats hesitate to eat diets containing papain (a cysteine protease) or capsaicin (a pungent principle of red pepper), but they ordinarily consume such diets from a few days after the onset of feeding, at which time cystatin S has been newly induced in their saliva. Induction of cystatin with a β-adrenergic agonist accelerates the beginning of eating a papain or capsaicin diet. Cystatin S is perhaps involved in protecting animals from injury caused by exogenous toxic or irritative substances. This article focuses on a few salivary proteins possibly involved in coping with toxic substances in food. In addition, participation of the salivary glands in the metabolism of lysine, an essential amino acid for rats and humans, will be discussed based on our recent data.

Journal

  • The journal of Gifu Dental Society

    The journal of Gifu Dental Society 30, 277-289, 2004-11-20

    Asahi University

References:  73

Codes

  • NII Article ID (NAID)
    110004689657
  • NII NACSIS-CAT ID (NCID)
    AN00053070
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    03850072
  • Data Source
    CJP  NII-ELS 
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