Effects of a structured psychiatric intervention on immune function of cancer patients
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- HOSAKA T
- Department of Psychiatry and Behavioral Science
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- TOKUDA Yutaka
- Department of Surgery, Tokai University School of Medicine
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- SUGIYAMA Yoko
- Department of Surgery, Tokai University School of Medicine
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- HIRAI Kei
- Faculty of Human Sciences, Osaka University
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- OKUYAMA Toru
- Department of Psychiatry and Behavioral Science
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抄録
The aim of the present study was to examine the influence of mood state and coping styles on the immune function in Japanese breast cancer patients who participated in a structured group intervention program. The program consisted of five-weekly 90-minute sessions, including psycho-education, psychological support, problem-solving technique and relaxation/imagery. Out of 77 breast cancer patients who participated in this program, 34 were eligible for measurement of immune functions because they received adjuvant chemotherapy. Comparison of the pre- and post-intervention scores of the Profile of Mood States (POMS) revealed significant decreases in Depression (p<0.05), Lack-of-Vigor (p<0.01), Tension-Anxiety (p<0.01), Confusion (p<0.05) and Total Mood Disturbances (p<0.01), as expected. Concerning coping styles, there were tendencies to decrease the score of active-cognitive coping (p=0.09), although the differences were not statistically significant. In contrast, the pre- and post-intervention values of immune parameters such as CD3, CD4, CD8, CD4/8 and natural-killer cell activity showed no significant differences. In this report, we discuss several possibilities underlying these findings. Further studies with a larger number of subjects and controls are needed to reach conculusions.
収録刊行物
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- Tokai J. Exp. Clin. Med.
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Tokai J. Exp. Clin. Med. 25 183-188, 2000
東海大学
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詳細情報
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- CRID
- 1572824501827107072
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- NII論文ID
- 110004700304
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- NII書誌ID
- AA00863975
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- ISSN
- 03850005
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- 本文言語コード
- en
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- データソース種別
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