歯周炎に対するLS‐007の有効性と有用性に関する臨床的ならびに細菌学的検討

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  • Clinical and microbiological study on effectiveness and usefulness of LS-007 for periodontitis.

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LS-007, containing 2% titers of minocycline hydrochloride (MINO) was applied locally to 46 patients for the treatment of periodontitis. The clinical and microbiological effectiveness, safety and usefulness of LS-007 were examined in two delivery systems: in one system LS-007 was delivered every one week (total 4 times), and in another system it was done every two weeks (total 3 times).<BR>In the sites to which LS-007 were applied, significant improvement in gingival inflammation, probing depth, and other clinical features were observed. Furthermore, numbers of periodontopathic bacteria including Bacteroides gingivalis were also effectively eliminated in the sites. In the safty test, there was only one subject who felt uncomfortable.<BR>In addition, antimicrobial activities of MINO and other antibiotics were evaluated by determining minimal inhibitory concentrations against those bacteria. Among the antibiotics tested, MINO revealed strong and broad antimicrobial activities against the bacterial species tested.<BR>From these results, LS-007 was clinically and microbiologically effective, safe and useful for the treatment of periodontitis.

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