Application of <i>aldehyde dehydrogenase 2 (ALDH2)</i> Genetic Diagnosis in Support of Decreasing Alcohol Intake
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- Komiya Yasuhiro
- Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazaki
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- Nakao Hiroyuki
- Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazaki
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- Kuroda Yoshiki
- Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazaki
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- Arizono Katsuyuki
- Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazaki
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- Nakahara Ai
- Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazaki
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- Katoh Takahiko
- Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazaki
書誌事項
- タイトル別名
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- Application of aldehyde dehydrogenase 2 (ALDH2) Genetic Diagnosis in Support of Decreasing Alcohol Intake
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Encouraging behavioral changes to decrease alcohol intake is not easy from the standpoint of health support. This study was conducted to examine whether the genetic diagnosis of ALDH2 polymorphism is useful in supporting those who want to decrease their alcohol intake. The participants in this study were 329 male employees who wanted to know the result of their ALDH2 genotype. We divided the 329 participants randomly into two groups. One was the "notified group" (n=157), and the other was the "non-notified group" (n=172). The subjects belonging to the "notified group" were informed of the results of the ALDH2 genotype diagnosis in April, 2003. Drinking habits and laboratory data were obtained before and after notification of the ALDH2 genotype. Among those with genotype ALDH2*1/*1, there was no significant change in drinking frequencies, nor was there any significant decline in liver function laboratory data in either of the groups before and after notification of the genotype. However, weekly alcohol intake tended to increase compared to that before notification. On the other hand, with regard to those with genotype ALDH2*1/*2, no significant changes in drinking frequencies or liver function laboratory data were evident in either group before and after notification of the genotype. However, the weekly alcohol intake tended to increase in the non-notified group, whereas it tended to decrease in the notified group. Although the result was not significant, it is suggested that, with further study and an increased sample size, the genetic diagnosis may be found to be useful.<br>
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 48 (3), 161-165, 2006
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390001204455049856
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- NII論文ID
- 130004447344
- 110004729536
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 7945299
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可