Inhibitory Effects of Exercise-preconditioning before Hindlimb Suspension on Ubiquitin-proteasome Pathway Activity in Muscle Atrophy

• FUJINO Hidemi

  Faculty of Health Science, Suzuka University of Medical Sciences:Institute of Traditional Medicine, Suzuka University of Medical Sciences:Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• KOHZUKI Hisaharu

  Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences:Department of Food and Nutrition, Okayama Gakuin University

• TAKEDA Isao

  Faculty of Health Science, Suzuka University of Medical Sciences

• TASAKI Hiromitsu

  Faculty of Health Science, Suzuka University of Medical Sciences

• KONDO Hiroyo

  Faculty of Health Science, Suzuka University of Medical Sciences

• ISHIDA Torao

  Institute of Traditional Medicine, Suzuka University of Medical Sciences

• KAJIYA Fumihiko

  Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences:Department of Medical Engineering, Kawasaki Medical School, and Kawasaki College of Allied Health Professions

Bibliographic Information

Other Title

• 尾部懸垂前の運動が廃用性萎縮筋のユビキチン-プロテアソーム系に及ぼす抑制効果

Abstract

Exercise-preconditioning attenuates muscle atrophy due to hindlimb suspension (HS). However, the molecular mechanism by which exercise-preconditioning exerts these effects remains poorly understood. The present study investigated whether exercise-preconditioning attenuates HS-induced muscle atrophy via inhibition of the ubiquitin-proteasome pathway and whether heat shock protein (HSP) mediates this inhibition in rat soleus muscle. <br>Rats were randomized to the following groups: 2-wk HS, treadmill running before 2-wk HS, and aged-matched control. HS-induced atrophy was associated with increased proteolysis (decreased myofibrillar protein), upregulation of components of the ubiquitin-proteasome pathway (ubiquitin ligase E3 mRNA activity) and downregulation of HSP72 mRNA in the soleus muscle. However, exercise-preconditioning attenuated HS-induced atrophy and reduced ubiquitin ligase E3 mRNA. Furthermore, exercise-preconditioning did not decrease HSP72 mRNA. <br>These findings suggest that exercise-preconditioning attenuates HS-induced atrophy through muscle-specific inhibition of the ubiquitin-proteasome pathway, and is an effective countermeasure to muscle atrophy induced by HS.

Journal

• Physical Therapy Japan

  Physical Therapy Japan 33 (2), 76-81, 2006-04-20

  Japanese Society of Physical Therapy

Keywords

• ユビキチンリガーゼ
• 熱ストレスタンパク質
• mRNA

Details

• CRID: 1390001288058226944
• NII Article ID: 110004735540
• NII Book ID: AN10146032
• DOI: 10.15063/rigaku.kj00004317393
• ISSN: 2189602X
• ISSN: 02893770
• Web Site: https://search.jamas.or.jp/link/ui/2006209981
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed