気道狭窄の動的座屈モデルによる解析  [in Japanese] Analysis of Airway Narrowing Based on Dynamic Buckling Model  [in Japanese]

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Author(s)

Abstract

In order to elucidate the mechanism of airway narrowing in asthma, dynamic buckling analysis was performed for basement membrane. The basement membrane was treated as two-dimensional circular thin-walled viscoelastic shell of Voigt model and contraction of smooth muscle was replaced by inward transmural pressure applied to the basement membrane. Governing equations for the dynamic buckling was derived and wave number of buckling mode obtained were compared with numerical simulation results by non-linear FEM and with experimental results. The non-dimensional parameters are thickness radius ratio, non-dimensional increasing speed of inward transmural pressure, non-dimensional retardation time and Poisson ratio. Wave number of buckling mode is determined as the number having maximum amplification from initial imperfection mode. The wave number of buckling mode increases with increase in non-dimensional increasing speed of inward transmural pressure and it decreases with increase in non-dimensional retardation time. It has been known that wave number of buckling mode decreases due to thickening and hardening of basement membrane caused by the remodeling in asthma. This fact is originated from decrease in non-dimensional increasing speed of inward transmural pressure due to the remodeling. In the dynamic buckling analysis the damping effect of the basement membrane is necessary to take into consideration, because the primary component of the basement membrane is collagen having damping characteristics.

Journal

  • Transactions of the Japan Society of Mechanical Engineers C

    Transactions of the Japan Society of Mechanical Engineers C 72(717), 1462-1469, 2006-05-25

    The Japan Society of Mechanical Engineers

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  • Numerical Simulation for Mechanism of Airway Narrowing in Asthma  [in Japanese]

    BANDO Kiyoshi , YAMASHITA Daisuke , OHBA Kenkichi

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Codes

  • NII Article ID (NAID)
    110004738280
  • NII NACSIS-CAT ID (NCID)
    AN00187463
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03875024
  • NDL Article ID
    7973625
  • NDL Source Classification
    ZN11(科学技術--機械工学・工業)
  • NDL Call No.
    Z16-1056
  • Data Source
    CJP  CJPref  NDL  NII-ELS 
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