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- Sakai Tohru
- Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School Department of Clinical Nutrition, Osaka Prefecture University
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- Kogiso Mari
- Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
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- Mitsuya Kaori
- Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
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- Komatsu Tatushi
- Department of Clinical Nutrition, Osaka Prefecture University
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- Yamamoto Shigeru
- Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
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The NC/Nga mouse is a model animal for human atopic dermatitis. In this study, we investigated oral tolerance induction in NC/Nga mice. In BALB/c mice, oral administration of ovalbumin (OVA) resulted in suppression of both OVA-specific T and B cell responses induced by OVA immunization. In NC/Nga mice, OVA-induced antigen (Ag) -specific T and B cell responses were significantly less than those in BALB/c mice. Furthermore, oral administration of OVA did not suppress OVA-specific immunoresponses in NC/Nga mice. We further examined antibody (Ab) response against food Ag by feeding mice an experimental diet that contained OVA or casein as a protein source. The level of serum OVA or casein-specific IgG was significantly higher in NC/Nga mice than in BALB/c mice. These results indicate that NC/Nga mice have a defect in the induction of oral tolerance. NC/Nga mice can therefore be used as a model for investigating the mechanism of oral tolerance. J. Med. Invest. 53: 29-33, February, 2006
収録刊行物
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 53 (1-2), 29-33, 2006
国立大学法人 徳島大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390282679220426880
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- NII論文ID
- 110004739302
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- NII書誌ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可