Germ Cell Loss Induced by 12C〔6+〕 Ion Irradiation in Young Female Mice

• ZHANG Hong

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• ZHANG Xu

  Department of Pathology, Lanzhou University

• YUAN Zhigang

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• LI Xiaoda

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• LI Wenjian

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• ZHOU Qingming

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• MIN Fengling

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• XIE Yi

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• LIU Bing

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

• DUAN Xin

  Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences

書誌事項

タイトル別名

• Germ Cell Loss Induced by 12C6+ Ion Irradiation in Young Female Mice

抄録

The ovaries of Kun-Ming strain mice (3 weeks) were irradiated with different doses of ¹²C⁶⁺ ion in the Bragg peak or the plateau region. At 10th day after irradiation, ovarian and uterine weights were measured; normal and atretic (identified with the oocyte to be degenerating or absent) primordial, primary and preantral follicles were identified in the largest cross-section of each ovary. Percentage (%) of normal follicles of each developmental stage of oogenesis was calculated. The data showed that compared to controls, there was a dose-related decrease in percentage of normal follicles in each developmental stage. And the weights of ovary and uterus were also reduced with doses of irradiation. Moreover, these effects were much more significant in the Bragg peak region and the region close to the Bragg peak than in the beam's entrance (the plateau region). Radiosensitivity varied in different follicle maturation stages. Primordial follicles, which are thought to be extremely sensitive to ionizing irradiation, were reduced by 86.6%, while primary and preantral follicles reduced only by 72.5% and 61.8% respectively, by exposure with 6 Gy of ¹²C⁶⁺ ion in the Bragg peak region and the region close to the Bragg peak. The data suggested that due to their optimal depth-dose distribution in the Bragg peak region, heavy ions are ones of the best particles for radiotherapy of tumors located next of vital organs or/and surrounded by normal tissues, especially radiosensitive tissues such as gonads.<br>

収録刊行物

• Journal of Radiation Research

  Journal of Radiation Research 47 (2), 131-134, 2006

  Journal of Radiation Research 編集委員会

キーワード

• ¹²C⁶⁺ heavy ion
• Germ cell loss
• Female mice

詳細情報

• CRID: 1390001205217770368
• NII論文ID: 110004740240
• NII書誌ID: AA00705792
• DOI: 10.1269/jrr.47.131
• ISSN: 13499157
• ISSN: 04493060
• NDL書誌ID: 7960277
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7960277
• Web Site: http://academic.oup.com/jrr/article-pdf/47/2/131/2700332/jrr-47-131.pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10918799
• Web Site: https://search.jamas.or.jp/link/ui/2007159741
• 本文言語コード: en
• データソース種別:
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