The maintenance of genome integrity is tissue-specific The Maintenance of Genome Integrity is Tissue-Specific

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Author(s)

Abstract

In order to understand how mutagens behave and act <i>in vivo</i>, it is important to understand how the integrity of the genome is maintained and protected in each specific tissue. Although several lines of evidence suggest that the systems used to protect and maintain the genome can change or are modified during cellular differentiation processes, and when cells alter their status from a proliferating to a non-proliferating state, data on individual tissues is very limited. Recent studies on the age-dependent accumulation of spontaneous mutations in transgenic mice clearly indicate that there is tissue-specificity when examining genome maintenance and protection. The genome is most unstable in epithelial tissues of the small and large intestine when compared to 13 other organs and tissues. The genome is highly protected in brain, skin and testis. Studies of the molecular nature of specific mutations suggest the presence of unique tissue-specific mechanisms leading to the formation of mutations in specific tissues. Studies of mutations in DNA repair gene deficient mice have shown that some of the genes involved in mismatch repair are indispensable in many tissues for the maintenance of the genome. The <i>Xpa</i> and <i>Xpc</i> genes involved in nucleotide excision repair have also been shown to be important in some tissues. However, the studies reported to date are only a beginning, and a complete comprehensive picture of the maintenance and repair of the genomic integrity in individual tissues remains to be developed.<br>

Journal

  • Genes and Environment

    Genes and Environment 28(1), 16-22, 2006-02-28

    The Japanese Environmental Mutagen Society

References:  38

Codes

  • NII Article ID (NAID)
    110004740318
  • NII NACSIS-CAT ID (NCID)
    AN1006217X
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    18807046
  • NDL Article ID
    7878086
  • NDL Source Classification
    ZR1(科学技術--生物学)
  • NDL Call No.
    Z78-A397
  • Data Source
    CJP  NDL  NII-ELS  IR  J-STAGE 
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