広範囲な口腔内疾患に適用可能なメフェナム酸鎮痛スプレーの調製と臨床評価  [in Japanese] Preparation of Mefenamic Acid Sprays as Analgesic for Wide Range of Oral Diseases and Their Clinical Evaluation  [in Japanese]

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Author(s)

Abstract

In order to relieve oral mucosal pain topically, we prepared a 2% mefenamic acid (MA) spray using carboxyvinyl polymer (CP, 0.25% and 0.5%) and compared it with a MA spray prepared using sodium polyacrylate (PANa, 0.2%). In the stability and dispersion tests, the MA content of the 0.25% and 0.5% CP sprays had not changed 28 days after preparation under 5 test conditions (4°C without shading, 25°C without shading, 37°C without shading, 4°C with shading, 25°C with shading). However, the MA content of the spray prepared using 0.2% PANa had decreased 3 days after preparation, demonstrating that CP was better as a dispersion agent. When the sprays were used for healthy volunteers, the salivary concentration of MA for the 0.5% CP spray was higher than that achieved with the 0.25% CP spray (0.25% CP : 3.47±1.03 mg, 0.5% CP : 4.98±1.23 mg, P<0.05).<br>The clinical efficacy was tested in 89 out-patients (age ranging from 18 to 91 years) with eight different diseases exhibiting oral mucosal pain, who received the 0.25% CP spray (n=48) or the 0.5% CP spray (n=41). Sixty-one patients showed an analgesic effect on application of MA spray (0.25% CP : 30 patients, 0.5% CP : 31 patients) and the mean onset of action was 1'58"±1'10" (0.25% CP : 1'56"±1'13", 0.5% CP : 2'01"±1'09").<br>In the case of hyperesthesia and decubitus ulcer, the analgesic effect was 100% suggesting that regardless of the concentration, MA sprays using CP are very effective in patients with oral mucosal pain other than that due to oral mucostitis.

Journal

  • Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 32(7), 648-656, 2006-07-10

    Japanese Society of Pharmaceutical Health Care and Sciences

References:  10

Cited by:  1

Codes

  • NII Article ID (NAID)
    110004740982
  • NII NACSIS-CAT ID (NCID)
    AA11527197
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    1346342X
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE  NDL-Digital 
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