Elevated Plasma Osteopontin Levels Were Associated With Osteopontin Expression of CD4+ T Cells in Patients With Unstable Angina

• Soejima Hirofumi

  Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Health Care Center, Kumamoto University

• Irie Atsushi

  Departments of Neuroscience Immunology, Graduate School of Medical Sciences, Kumamoto University

• Fukunaga Takashi

  Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Sugamura Koichi

  Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Kojima Sunao

  Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Sakamoto Tomohiro

  Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Yoshimura Michihiro

  Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Kishikawa Hideki

  Health Care Center, Kumamoto University

• Nishimura Yasuharu

  Departments of Neuroscience Immunology, Graduate School of Medical Sciences, Kumamoto University

• Ogawa Hisao

  Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

抄録

Background Plaque instability in patients with unstable angina (UA) is associated with stimulated CD4⁺ T cells, so the present study investigated whether there is a relationship among plaque instability, osteopontin and CD4⁺ T cells. Methods and Results Peripheral blood mononuclear cells were collected from 51 consecutive patients with UA, 60 patients with stable angina (SA), and 39 patients with chest pain syndrome (CPS). Osteopontin-producing CD4⁺ T cells were quantified by flow cytometry. Plasma osteopontin levels (ng/ml) were measured by ELISA and were higher in patients with UA (792.0±316.7) than in those with SA (626.0±195.0, p<0.005) or CPS (594.7±239.4, p<0.005). The frequency (%) of osteopontin-producing CD4⁺ T cells was higher in patients with UA (26.7±13.3) than in those with SA (19.5±11.1, p<0.05) or CPS (16.6±9.0, p<0.005). Furthermore, the plasma osteopontin level correlated with the frequency of osteopontin-producing CD4⁺ T cells (r=0.327, p=0.0004), as did the high-sensitivity C-reactive protein level (r=0.360, p=0.0002). Conclusions The plasma osteopontin levels are elevated in patients with UA, accompanied by an increase in the number of osteopontin-production of circulating CD4⁺ T cells. Circulating CD4⁺ T cells may play a role through osteopontin in the pathophysiology of UA. (Circ J 2006; 70: 851 - 856)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 70 (7), 851-856, 2006

  一般社団法人 日本循環器学会

キーワード

• Osteopontin
• T cell
• Unstable angina

詳細情報

• CRID: 1390282680078925056
• NII論文ID: 110004741049
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.70.851
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/70/7/70_7_851/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006315027
• 本文言語コード: en
• データソース種別:
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