Elevated Plasma Osteopontin Levels Were Associated With Osteopontin Expression of CD4^+ T Cells in Patients With Unstable Angina

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Author(s)

    • SOEJIMA Hirofumi
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    • IRIE Atsushi
    • Department of Neuroscience Immunology, Graduate School of Medical Sciences, Kumamoto University
    • FUKUNAGA Takashi
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    • SUGAMURA Koichi
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    • KOJIMA Sunao
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    • SAKAMOTO Tomohiro
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    • YOSHIMURA Michihiro
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
    • NISHIMURA Yasuharu
    • Department of Neuroscience Immunology, Graduate School of Medical Sciences, Kumamoto University
    • OGAWA Hisao
    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

Abstract

<b>Background</b> Plaque instability in patients with unstable angina (UA) is associated with stimulated CD4<sup>+</sup> T cells, so the present study investigated whether there is a relationship among plaque instability, osteopontin and CD4<sup>+</sup> T cells. <b>Methods and Results</b> Peripheral blood mononuclear cells were collected from 51 consecutive patients with UA, 60 patients with stable angina (SA), and 39 patients with chest pain syndrome (CPS). Osteopontin-producing CD4<sup>+</sup> T cells were quantified by flow cytometry. Plasma osteopontin levels (ng/ml) were measured by ELISA and were higher in patients with UA (792.0±316.7) than in those with SA (626.0±195.0, p<0.005) or CPS (594.7±239.4, p<0.005). The frequency (%) of osteopontin-producing CD4<sup>+</sup> T cells was higher in patients with UA (26.7±13.3) than in those with SA (19.5±11.1, p<0.05) or CPS (16.6±9.0, p<0.005). Furthermore, the plasma osteopontin level correlated with the frequency of osteopontin-producing CD4<sup>+</sup> T cells (r=0.327, p=0.0004), as did the high-sensitivity C-reactive protein level (r=0.360, p=0.0002). <b>Conclusions</b> The plasma osteopontin levels are elevated in patients with UA, accompanied by an increase in the number of osteopontin-production of circulating CD4<sup>+</sup> T cells. Circulating CD4<sup>+</sup> T cells may play a role through osteopontin in the pathophysiology of UA. (<i>Circ J</i> 2006; <b>70:</b> 851 - 856)<br>

Journal

  • Circulation Journal

    Circulation Journal 70(7), 851-856, 2006-06-20

    Japanese Circulation Society

References:  38

Cited by:  3

Codes

  • NII Article ID (NAID)
    110004741049
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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