Prediction of Cognitive Function by Arterial Stiffness in the Very Elderly

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Author(s)

    • FUKUHARA Masayo
    • Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • MATSUMURA Kiyoshi
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • ANSAI Toshihiro
    • Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • TAKATA Yutaka
    • Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • SONOKI Kazuo
    • Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • AKIFUSA Sumio
    • Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • WAKISAKA Masanori
    • Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • HAMASAKI Tomoko
    • Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • FUJISAWA Kiyoshi
    • Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • YOSHIDA Akihiro
    • Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College
    • FUJII Koji
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • IIDA Mitsuo
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • TAKEHARA Tadamichi
    • Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

Abstract

<b>Background</b> Cognitive function is impaired in elderly subjects, so the aim of the present study was to determine the role of arterial stiffness on cognitive function. <b>Methods and Results</b> Cognitive function and arterial stiffness were assessed by the Mini-Mental State Examination (MMSE) and measurement of the brachial - ankle pulse wave velocity (PWV), respectively. The cross-sectional association of the MMSE score and PWV was studied in 203 subjects (87 men, 116 women), all of whom were 85 years old. Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score ≥24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group than in the normal MMSE group (25.0±0.8 vs 22.9±0.5 m/s, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score. <b>Conclusions</b> These results suggest that cognitive function could be predicted by arterial stiffness, as assessed by the PWV, in the very old. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age. (<i>Circ J</i> 2006; <b>70:</b> 756 - 761)<br>

Journal

  • Circulation Journal

    Circulation Journal 70(6), 756-761, 2006-05-20

    Japanese Circulation Society

References:  37

Cited by:  3

Codes

  • NII Article ID (NAID)
    110004750154
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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