Prediction of Cognitive Function by Arterial Stiffness in the Very Elderly

• Fukuhara Masayo

  Divisions of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Matsumura Kiyoshi

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Ansai Toshihiro

  Divisions of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Takata Yutaka

  Divisions of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Sonoki Kazuo

  Divisions of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Akifusa Sumio

  Divisions of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Wakisaka Masanori

  Divisions of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Hamasaki Tomoko

  Divisions of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Fujisawa Kiyoshi

  Divisions of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Yoshida Akihiro

  Divisions of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

• Fujii Koji

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Iida Mitsuo

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Takehara Tadamichi

  Divisions of Community Oral Health Science, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College

Abstract

Background Cognitive function is impaired in elderly subjects, so the aim of the present study was to determine the role of arterial stiffness on cognitive function. Methods and Results Cognitive function and arterial stiffness were assessed by the Mini-Mental State Examination (MMSE) and measurement of the brachial - ankle pulse wave velocity (PWV), respectively. The cross-sectional association of the MMSE score and PWV was studied in 203 subjects (87 men, 116 women), all of whom were 85 years old. Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score ≥24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group than in the normal MMSE group (25.0±0.8 vs 22.9±0.5 m/s, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score. Conclusions These results suggest that cognitive function could be predicted by arterial stiffness, as assessed by the PWV, in the very old. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age. (Circ J 2006; 70: 756 - 761)<br>

Journal

• Circulation Journal

  Circulation Journal 70 (6), 756-761, 2006

  The Japanese Circulation Society

Keywords

• Arterial stiffness
• Cognitive impairment
• Elderly
• Mini-Mental State Examination
• Pulse wave velocity

Details

• CRID: 1390282680082148096
• NII Article ID: 110004750154
• NII Book ID: AA11591968
• DOI: 10.1253/circj.70.756
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/70/6/70_6_756/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007115766
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed