An Interpretation of Evolutionary Dynamics in in vitro Molecular Evolution from Thermodynamical and Informational View Point
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- AITA Takuyo
- Computational Biology Research Center (CBRC) National Institute of Advanced Industrial Science and Technology (AIST) Present affiliation: Rational Evolutionary Design of Advanced Biomolecules (REDS) Group/JST, Saitama Small Enterprise Promotion Corporation SKIP
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- HUSIMI Yuzuru
- Department of Functional Materials Science, Saitama University
Bibliographic Information
- Other Title
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- 実験室内分子進化過程の熱力学的および情報論的解釈
- ジッケン シツナイ ブンシ シンカ カテイ ノ ネツリキガクテキ オヨビ ジョウホウロンテキ カイシャク
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Abstract
In vitro protein evolution is comprehended as a hill-climbing process on a fitness landscape in sequence space, just like the protein folding is comprehended as a valley-descending process on an energy landscape in comformation space. In this review, based on a mathematical model for in vitro molecular evolution, we demonstrated an analogy between evolutionary dynamics and thermodynamics and then many concepts in evolutionary dynamics became comprehensible. By introducing thermodynamics-like concepts such as “free fitness”, it is interpreted that evolution is driven in the direction in which free fitness increases. In this process, the evolving population climbs the fitness landscape by absorbing “fitness information” as the negative entropy from the surroundings as an experimental set-up.<br>
Journal
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- Seibutsu Butsuri
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Seibutsu Butsuri 46 (3), 137-143, 2006
The Biophysical Society of Japan General Incorporated Association
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Details 詳細情報について
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- CRID
- 1390001206536030464
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- NII Article ID
- 120006385826
- 110004750167
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- NII Book ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL BIB ID
- 7976473
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed