高LET放射線で誘発した(C57BL/6N x C3H/HeN)F1マウス肝腫瘍の経時的生存率

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献3件 参考文献60件
  • NITTA Yumiko
    International Radiation Information Center, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • SATOH Kenichi
    Division of Bio-Medical Informatics, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • SUGA Shinji
    Radiation Research Center for Frontier Science Facilities for Radiation Experiments, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • ENDO Satoru
    Division of Radiation Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University
  • NITTA Kohsaku
    Senogawa Hospital, Senogawa Medical Corporation

書誌事項

タイトル別名
  • Comparison of the Effectiveness of High and Low LET Radiations for the Proportion of Survivals with Liver Tumors at Every Age in (C57BL/6N * C3H/HeN)F1 Mice
  • Comparison of the Effectiveness of High and Low LET Radiations for the Proportion of Survivals with Liver Tumors at Every Age in (C57BL/6N×C3H/HeN)F1 Mice

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To investigate the late effects of neutrons at the energy below 1 MeV on the liver carcinogenesis as a function of age, one-week old mice were exposed to 1.0 Gy monoenergetic neutrons (0.317, 0.525 and 1.026 MeV) or 137Cs gamma rays. Survival and carcinogenesis were examined by 18 months of age. Following radiation, tumor incidences in liver, Harderian gland, lung, ovary and pituitary gland were compared. The proportion of the lifespan with liver tumors exposed to neutrons to that exposed to gamma rays was calculated as a function of age. Survival rates among the three groups exposed to neutrons of different energies were not significantly different from one another but shorter than those treated with gamma rays for both sexes. With regard to liver tumor incidence evaluated at 18 months of age, the effectiveness of neutrons to gamma rays was 2.54 for females, and 2.08 for males by the factor. Levels of estrogen in the serum were similar between mice bearing liver tumors and those devoid of tumors. In conclusion, all three energies of neutrons induced similar effectiveness with respect to liver carcinogenicity. Proportions of the lifespan with liver tumors of neutron-exposed to gamma-exposed were shorter in females than males along with ages over 12 months. To obtain this factor at every age contributed for the evaluation of the biological effectiveness of radiations with the parameter of tumor incidence and latency simultaneously.<br>

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