Effect of Green Tea Consumption on Endothelial Function and Circulating Endothelial Progenitor Cells in Chronic Smokers

DOI Web Site 被引用文献7件 参考文献45件
  • Kim Weon
    The Heart Center, Chonnam National University Hospital
  • Jeong Myung Ho
    The Heart Center, Chonnam National University Hospital
  • Cho Suk Hee
    The Heart Center, Chonnam National University Hospital
  • Yun Ji Hye
    The Heart Center, Chonnam National University Hospital
  • Chae Hong Jae
    The Heart Center, Departments of Occupational Environment Medicine, Chonnam National University Hospital
  • Ahn Young Keun
    The Heart Center, Chonnam National University Hospital
  • Lee Min Cheol
    The Heart Center, Departments of Pathology, Chonnam National University Hospital
  • Cheng Xianwu
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kondo Takahisa
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Murohara Toyoaki
    Department of Cardiology, Nagoya University Graduate School of Medicine
  • Kang Jung Chaee
    The Heart Center, Chonnam National University Hospital

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Background The present study was designed to investigate the effect and relationship of endothelial function and endothelial progenitor cells (EPCs) by green tea consumption in chronic smokers. The numbers of circulating EPCs have an inverse correlation with chronic smoking and endothelial dysfunction. Green tea catechin improved endothelial dysfunction in chronic smokers. Method and Results In 20 young healthy smokers, endothelial functions, defined by flow-mediated endothelium dependent vasodilation (FMD) of the brachial artery via ultrasound as well as the number of EPCs isolated from peripheral blood, were determined at baseline and at 2 weeks after green tea consumption (8 g/day). Circulating EPCs were quantified by flow cytometry as CD45lowCD34 + KDR2+ cells and by acyl-low-density lipoprotein and fluorescein isotiocyanate-lectin double positive cells after culture for 7 days. Clinical characteristics and laboratory findings were not significantly different between the baseline and at 2 weeks after green tea intake. EPC levels were inversely correlated with the number of cigarettes smoked. Circulating EPCs by flow cytometry (78.6 ±72.6 vs 156.1±135.8 /ml, p<0.001) and cultured EPCs (118.2±35.7 vs 169.31±58.3/10 field, p<0.001) increased rapidly at 2 weeks after green tea consumption. FMD was significantly improved after 2 weeks (7.2±2.8 vs 9.3±2.4, p<0.001). The FMD correlated with EPC counts (r=0.67, p=0.003) before treatment and after 2 weeks (r=0.60, p=0.013). Conclusions A short-term administration of green tea consumption induces a rapid improvement of EPC levels and FMD. Green tea consumption may be effective to prevent future cardiovascular events in chronic smokers. (Circ J 2006; 70: 1052 -1057)<br>

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  • Circulation Journal

    Circulation Journal 70 (8), 1052-1057, 2006

    一般社団法人 日本循環器学会

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