The Effects of Eicosapentaenoic Acid-Fortified Food on Inflammatory Markers in Healthy Subjects-A Randomized, Placebo-Controlled, Double-Blind Study

DOI Web Site 31 References
  • FUJIOKA Shuntaro
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • HAMAZAKI Kei
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • ITOMURA Miho
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • HUAN Mingming
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • NISHIZAWA Hiroto
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • SAWAZAKI Shigeki
    First Department of Internal Medicine, University of Toyama School of Medicine
  • KITAJIMA Isao
    Laboratory Medicine, University of Toyama School of Medicine
  • HAMAZAKI Tomohito
    Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama

Bibliographic Information

Other Title
  • Effects of Eicosapentaenoic Acid Fortified Food on Inflammatory Markers in Healthy Subjects A Randomized Placebo Controlled Double Blind Study

Search this article

Abstract

Epidemiological studies showed that habitual fish intakes were associated with lower blood inflammatory markers. In the present study the effects of a fish oil-containing food on inflammatory markers were investigated in healthy, mostly middle-aged subjects (59 men and 82 women) with normal to mildly elevated triglyceride levels. Study subjects were randomly allocated to two groups in a double-blind manner; one group ingested an eicosapentaenoic acid (EPA)-rich fish oil-fortified drink (0.60 g EPA+0.26 g docosahexaenoic acid/d, EPA group, n=68) for 12 wk. The rest of the subjects took a placebo (control group, n=73). Plasma levels of high sensitivity C-reactive protein (hs-CRP) and soluble tumor necrosis factor-receptors 1 and 2 (sTNF-Rs 1 and 2) were measured at the start and end of intervention. EPA concentrations in the total RBC phospholipid fraction significantly increased by 79% in the EPA group at the end of the study, and they changed very little in the control group (+0.68%). The inflammatory markers did not change in either group. It is likely that fish oil does not change hs-CRP or sTNF-Rs 1 or 2 in subjects without active inflammation.

Journal

References(31)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top