Analysis of Photomutagenicity of Thiabendazole with UVA Irradiation: Absence of 8-Hydroxyguanosine Formation

• Watanabe-Akanuma Mie

• Inaba Yohei

  Tokyo University of Pharmacy and Life Science

• Ohta Toshihiro

  Tokyo University of Pharmacy and Life Science

抄録

We recently reported the photomutagenic property of thiabendazole [2-(4-thiazolyl)-1H-benzimidazole, TBZ], a post harvest fungicide, in bacterial and mammalian cells. In the present study we investigated its photomutagenic potential along with several of its structurally-related pesticides including benomyl, mefenacet, tricyclazole, and imazalil. None of the compounds except TBZ showed photomutagenicity with UVA-irradiation in S. typhimurium TA100, TA98, or E. coli WP2uvrA/pKM101. Since TBZ consists of thiazole and benzimidazole rings, we then investigated photomutagenic potential of thiazole, benzimidazole, and 2-phenylbenzimidazole. Only 2-phenylbenzimidazole showed very weak photomutagenicity with UVA-irradiation. These results indicate both benzimidazole ring and thiazole ring are necessary for UVA-activation of TBZ. We measured 8-hydroxydeoxyguanosine (8-OHdG) in salmon sperm DNA exposed to TBZ and UVA by HPLC-ECD, and found that 8-OHdG was not responsible for the photomutagenesis of TBZ.<br>

収録刊行物

• Genes and Environment

  Genes and Environment 28 (3), 103-107, 2006

  日本環境変異原学会

キーワード

• photomutagenicity
• UVA
• TBZ
• pesticide
• 8-OHdG

詳細情報

• CRID: 1390001205257104256
• NII論文ID: 130004481134
• NII論文ID: 110004793040
• NII書誌ID: AA1212552X
• DOI: 10.3123/jemsge.28.103
• ISSN: 18807062
• ISSN: 18807046
• NDL書誌ID: 8040005
• Web Site: http://id.ndl.go.jp/bib/8040005
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8040005
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可