野菜フラボノイドの生体利用性と抗酸化活性  [in Japanese] Bioavailability and Antioxidative Activity of Flavonoids from Vegetables  [in Japanese]

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Author(s)

    • 東 敬子 Azuma Keiko
    • (独)野菜茶業研究所機能解析部・野菜機能解析研究室 National Agriculture and Food Research Organization, National Institute of Vegetable and Tea Science
    • 室田 佳恵子 Murota Kaeko
    • 徳島大学大学院ヘルスバイオサイエンス研究部・食品機能学分野 Department of Food Science, Graduate School of Nutrition and Bioscience, Institute of Health Biosciences, The University of Tokushima
    • 寺尾 純二 Terao Junji
    • 徳島大学大学院ヘルスバイオサイエンス研究部・食品機能学分野 Department of Food Science, Graduate School of Nutrition and Bioscience, Institute of Health Biosciences, The University of Tokushima

Abstract

Vegetables contain a variety of flavonoids, such as flavonols, flavones and anthocyanidins. Numerous in vitro studies have revealed diverse biochemical actions of flavonoids, and their antioxidant activity should be, at least partly, responsible for these actions. We are interested in quercetin (3, 3', 4', 5, 7-pentahydroxyflavone), a flavonol-type flavonoid as an anti-atherosclerotic food factor and have examined its bioavailability to evaluate the biological effect. Quercetin and other flavonoids frequently exist as their glycoside forms in vegetables. Glucoside-bound quercetin is absorbed and hydrolyzed in small intestine through glucose-transport system or passive transport after lactase phlorizin hydrolase (LPH)-dependent deglucosidation. Quercetin glycosides other than glucoside forms are likely to be absorbed in large intestine after hydrolysis with enterobacteria. Efficiency of the absorption is considerably affected by the coexisting food components. Lipids and emulsifiers were found to enhance the absorption. In any cases, resulting quercetin aglycone is converted to conjugated glucuronides and/or sulfates during the process of their absorption. Some metabolites circulating in the blood stream can act as free radical scavengers, as well as the inhibitors of lipoxygenase and xanthine oxidase. It is therefore likely that biological effect of quercetin is originated from conjugated metabolites. Metabolic conversion of flavonoids to their conjugates may be a process for regulating their action on cellular oxidative stress.

Journal

  • VITAMINS

    VITAMINS 80(8), 403-410, 2006

    THE VITAMIN SOCIETY OF JAPAN

References:  46

Cited by:  2

Codes

  • NII Article ID (NAID)
    110004793369
  • NII NACSIS-CAT ID (NCID)
    AN00207833
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0006-386X
  • NDL Article ID
    8076882
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-36
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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