カリクレインのラット神経幹細胞増殖促進作用  [in Japanese] Growth-stimulating Effect of Kallikrein on Rat Neural Stem Cells  [in Japanese]

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Author(s)

    • 木付 和幸 KIZUKI Kazuyuki
    • 山口東京理科大学基礎工学部, 物質・環境工学科 Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science
    • 大久保 隆一 OOKUBO Ryuuichi
    • 山口東京理科大学基礎工学部, 物質・環境工学科 Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science
    • 岩館 寛大 [他] IWADATE Hiromoto
    • 山口東京理科大学基礎工学部, 物質・環境工学科 Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science
    • 貞 啓介 SADA Keisuke
    • 山口東京理科大学基礎工学部, 物質・環境工学科 Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, Tokyo University of Science

Abstract

  Tissue kallikrein is expressed in many species and is widely distributed throughout the body, including the brain. In general, this protease is well known to release the vasoactive peptide, kinin, from kininogen. We report here that kallikrein has a prominent growth-stimulating effect on neural stem cells prepared from the brains of prenatal rats. This growth-stimulating effect was suppressed by antiserum against rat tissue kallikrein. Since bradykinin B<sub>2</sub>-receptor antagonist, Hoe140, did not suppress the growth-stimulating effect, kallikrein-mediated kinin release does not appear to be involved in this effect. Thus, our data suggest a new physiological function of kallikrein, the growth of neural stem cells. Such involvement would suggest that kallikrein is not only potentially involved in an important function of brain development, but also available for studies on regenerative medicine for neurons.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 126(10), 997-1001, 2006-10-01

    The Pharmaceutical Society of Japan

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Codes

  • NII Article ID (NAID)
    110004811924
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00316903
  • NDL Article ID
    8537749
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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