ラット一過性中大脳動脈閉塞モデルにおける再還流後の組織中低酸素領域の検出

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献3件 参考文献38件
  • NOTO Takahisa
    Medicinal Biology Research Laboratories, Astellas Pharmaceutical Inc.
  • FURUICHI Yasuhisa
    Medicinal Biology Research Laboratories, Astellas Pharmaceutical Inc.
  • ISHIYE Masayuki
    Medicinal Biology Research Laboratories, Astellas Pharmaceutical Inc.
  • MATSUOKA Nobuya
    Medicinal Biology Research Laboratories, Astellas Pharmaceutical Inc.
  • ARAMORI Ichiro
    Medicinal Biology Research Laboratories, Astellas Pharmaceutical Inc.
  • MUTOH Seitaro
    Medicinal Biology Research Laboratories, Astellas Pharmaceutical Inc.
  • YANAGIHARA Takehiko
    Osaka Neurological Research Institute
  • MANABE Noboru
    Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo

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タイトル別名
  • Temporal and Topographic Profiles of Tissue Hypoxia Following Transient Focal Cerebral Ischemia in Rats

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Intravascular accumulation of blood cells after brain ischemia-reperfusion can cause obstruction of cerebral blood flow and tissue hypoxia/ischemia as a consequence. In the present study, we examined temporal and topographic changes of tissue hypoxia/ischemia after occlusion of the middle cerebral artery (MCA) for 60 min in rats with immunohistochemical staining for hypoxia (2-nitroimidazole hypoxia marker: hypoxyprobe-1 adducts). Our results showed that tissue hypoxia expressed as positive staining for hypoxyprobe-1 adducts preceded neuronal degeneration. Platelets and granulocytes were detected close to the hypoxyprobe-1 adducts positive area. These results suggested that the hypoxic environment could persist even after reperfusion of MCA, because of vascular obstruction with accumulation of platelets and granulocytes.<br>

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