Effects of MCI-186 (Edaravone), a Novel Free Radical Scavenger, Upon Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice

• Okabe Taka-aki

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Kishimoto Chiharu

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Shimada Kana

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Murayama Toshinori

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Yokode Masayuki

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Kita Toru

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

抄録

Background Recent evidence suggests that oxidative stress may play a role in the development of atherosclerosis. MCI-186 (3-methyl-1-phenyl-1-parazolin-5-one, edaravone) is a novel free radical scavenger, but it remains unclear whether free radical scavengers would be effective for the prevention of the disease. Methods and Results Experimental atherosclerosis was induced in apolipoprotein E-deficient mice fed a high-fat diet containing 0.3% cholesterol. Mice were treated with an intraperitoneal injection of either MCI-186 1 mg/kg per day or MCI-186 10 mg/kg per day on alternate days over 4 weeks. Fatty streak lesion was suppressed by MCI-186 10 mg/kg per day administration, but not by mg/kg per day. Immunohistochemical analysis showed that macrophage and CD4⁺ T-cell accumulation and oxidative stress overload in the fatty streak lesion were suppressed in mice that received MCI-186 treatment. Conclusions MCI-186 administration suppressed the development of atherosclerosis, associated with reduced expression of both immune-activated cells and oxidative stress in fatty streak plaques. (Circ J 2006; 70: 1216 - 1219)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 70 (9), 1216-1219, 2006

  一般社団法人 日本循環器学会

キーワード

• Atherosclerosis
• Free radical scavenger
• Oxidative stress

詳細情報

• CRID: 1390282680079366016
• NII論文ID: 110004814901
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.70.1216
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/70/9/70_9_1216/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007132371
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可