Synthesis, Characterization and in Vitro Cytotoxicity of Pentacoordinated Tin(IV) Complexes Derived from Aminoalcohols

• Gómez Elizabeth

  Instituto de Química-UNAM, Circuito Exterior, Ciudad Universitaria

• Contreras-Ordoñez Guadalupe

  Instituto de Química-UNAM, Circuito Exterior, Ciudad Universitaria

• Ramírez-Apan Teresa

  Instituto de Química-UNAM, Circuito Exterior, Ciudad Universitaria

書誌事項

タイトル別名

• Synthesis Characterization and in Vitro Cytotoxicity of Pentacoordinated Tin 4 Complexes Derived from Aminoalcohols

抄録

The synthesis of pentacoordinated Tin(IV) compounds derived from aminoalcohols is described. The compounds were characterized by IR, ¹H-, ¹³C-, and ¹¹⁹Sn-NMR, the mass spectrometry exhibits molecular ions corresponding to monomeric species. All compounds were evaluated for in vitro cytotoxic activities against five human tumor cell lines, U251 (human glioblastoma), PC-3 (human prostatic adenocarcinoma), K-562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma). The cytotoxic evaluation revealed that all compounds possess higher cytotoxic potency than that of the cisplatin, which was used as reference. Additionally, MT2 cells (human T-lymphocytes) were also evaluated.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 54 (1), 54-57, 2006

  公益社団法人 日本薬学会

キーワード

• cytotoxicity
• Tin(IV)
• pentacoordinated
• ¹¹⁹Sn-NMR

詳細情報

• CRID: 1390282679145165312
• NII論文ID: 110004820323
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.54.54
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 7756619
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7756619
• Web Site: http://www.jstage.jst.go.jp/article/cpb/54/1/54_1_54/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可