Relationship between Microtubule Network Structure and Intracellular Transport in Cultured Endothelial Cells Affected by Shear Stress

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Author(s)

Abstract

Endothelial cells (ECs) that line the inner surface of blood vessels are barriers to the transport of various substances into or from vessel walls, and are continuously exposed to shear stress induced by blood flow <i>in vivo</i>. Shear stress affects the cytoskeleton (e.g., microtubules, microfilaments, intermediate filaments), and affects the transport of macromolecules. Here, the relationship between the microtubule network structure and this transport process for albumin uptake within cultured aortic endothelial cells affected by shear stress was studied. Based on fluorescent images of albumin uptake obtained by using confocal laser scanning microscopy (CLSM), both the microtubule network and albumin uptake in ECs were disrupted by colchicine and were affected by shear stress loading.

Journal

  • JSME International Journal Series C

    JSME International Journal Series C 47(4), 977-984, 2004-12-01

    The Japan Society of Mechanical Engineers

References:  30

Codes

  • NII Article ID (NAID)
    110004820826
  • NII NACSIS-CAT ID (NCID)
    AA11179487
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13447653
  • NDL Article ID
    7190286
  • NDL Source Classification
    ZN11(科学技術--機械工学・工業)
  • NDL Call No.
    Z53-Y272
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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