Relationship between Microtubule Network Structure and Intracellular Transport in Cultured Endothelial Cells Affected by Shear Stress

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  • KUDO Susumu
    Department of Mechanical Engineering, Shibaura Institute of Technology
  • IKEZAWA Kenji
    Institute of Biomedical Engineering, Keio University
  • IKEDA Mariko
    Keio Leading-edge Laboratory of Science and Technology, Keio University
  • TANISHITA Kazuo
    Department of System Design Engineering, Keio University

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Endothelial cells (ECs) that line the inner surface of blood vessels are barriers to the transport of various substances into or from vessel walls, and are continuously exposed to shear stress induced by blood flow in vivo. Shear stress affects the cytoskeleton (e.g., microtubules, microfilaments, intermediate filaments), and affects the transport of macromolecules. Here, the relationship between the microtubule network structure and this transport process for albumin uptake within cultured aortic endothelial cells affected by shear stress was studied. Based on fluorescent images of albumin uptake obtained by using confocal laser scanning microscopy (CLSM), both the microtubule network and albumin uptake in ECs were disrupted by colchicine and were affected by shear stress loading.

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